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23 February 2010 In vivo label-free photoacoustic microscopy of the anterior segment of the mouse eye
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Abstract
Both iris fluorescein angiography (IFA) and indocyanine green angiography (ICGA) provide ophthalmologists imaging tools in studying the microvasculature structure and hemodynamics of the anterior segment of the eye in normal and diseased status. However, a non-invasive, endogenous imaging modality is preferable for the monitoring of hemodynamics of the iris microvasculature. We investigated the in vivo, label-free ocular anterior segment imaging with photo-acoustic microscopy (PAM) in mouse eyes. We demonstrated the unique advantage of endogenous contrast that is not available in both IFA and ICGA. The laser radiation was maintained within the ANSI laser safety limit. The in vivo, label-free nature of our imaging technology has the potential for ophthalmic applications.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Bin Rao, Song Hu, Li Li, Konstantin Maslov, and Lihong V. Wang "In vivo label-free photoacoustic microscopy of the anterior segment of the mouse eye", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75643E (23 February 2010); https://doi.org/10.1117/12.843052
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