23 February 2010 Photoacoustic characterization of human ovarian tissue
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Ovarian cancer has a five-year survival rate of only 30%, which represents the highest mortality of all gynecologic cancers. The reason for that is that the current imaging techniques are not capable of detecting ovarian cancer early. Therefore, new imaging techniques, like photoacoustic imaging, that can provide functional and molecular contrasts are needed for improving the specificity of ovarian cancer detection and characterization. Using a coregistered photoacoustic and ultrasound imaging system we have studied thirty-one human ovaries ex vivo, including normal and diseased. In order to compare the photoacoustic imaging results from all the ovaries, a new parameter using the RF data has been derived. The preliminary results show higher optical absorption for abnormal and malignant ovaries than for normal postmenopausal ones. To estimate the quantitative optical absorption properties of the ovaries, additional ultrasound-guided diffuse optical tomography images have been acquired. Good agreement between the two techniques has been observed. These results demonstrate the potential of a co-registered photoacoustic and ultrasound imaging system for the diagnosis of ovarian cancer.
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Andres Aguirre, Andres Aguirre, Yasaman Ardeshirpour, Yasaman Ardeshirpour, Mary M. Sanders, Mary M. Sanders, Molly Brewer, Molly Brewer, Quing Zhu, Quing Zhu, } "Photoacoustic characterization of human ovarian tissue", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75643G (23 February 2010); doi: 10.1117/12.845828; https://doi.org/10.1117/12.845828

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