Uncertainty analysis of time resolved transmittance characterization of solid tissue phantoms

Jean-Pierre Bouchard; Israël Veilleux; Isabelle Noiseux; Sébastien Leclair; Rym Jedidi; Michel Fortin; Ozzy Mermut

doi:10.1117/12.841969

24 February 2010 Uncertainty analysis of time resolved transmittance characterization of solid tissue phantoms

Jean-Pierre Bouchard, Israël Veilleux, Isabelle Noiseux, Sébastien Leclair, Rym Jedidi, Michel Fortin, Ozzy Mermut

Proceedings Volume 7567, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II; 75670A (2010) https://doi.org/10.1117/12.841969
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Solid tissue phantom are the preferred tool for the development, validation, testing and calibration of photon migration instrument. Accuracy, or trueness, of the optical properties of reference phantoms is of the utmost importance as they will be used as the conventional true value against which instrument errors will be evaluated. A detailed quantitative analysis of the uncertainty of time-resolved transmittance characterization of solid optical tissue phantom is presented. Random error sources taken into account are Poisson noise of the photon counting process, additive dark count noise and instrument response function stability. Systematic error sources taken into account are: phantom thickness uncertainty, refractive index uncertainty, time correlated single photon counting system time base calibration uncertainty. Correction procedures for these systematic errors are presented whenever a correction is possible.

Citation Download Citation

Jean-Pierre Bouchard, Israël Veilleux, Isabelle Noiseux, Sébastien Leclair, Rym Jedidi, Michel Fortin, and Ozzy Mermut "Uncertainty analysis of time resolved transmittance characterization of solid tissue phantoms", Proc. SPIE 7567, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II, 75670A (24 February 2010); https://doi.org/10.1117/12.841969

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