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25 February 2010 Optical modulation of smooth muscle cell contraction
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Even though electrical stimulation is generally used for induction of smooth muscle cell contraction, it is very hard to obtain fine control and also very invasive for inserting electrodes. Herein, we developed a new optical technology to control smooth muscle cell contraction. This optical method using femtosecond pulsed laser (FSPL) has advantage of focused stimulation and fine control of stimulation intensity. Upon brief exposure to FSPL, smooth muscle cells showed a rapid increase of intracellular calcium levels followed by cell contraction. Collectively, we suggest that FSPL can be a useful tool for control of smooth muscle cell contraction.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jonghee Yoon, Myunghwan Choi, and Chulhee Choi "Optical modulation of smooth muscle cell contraction", Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 75681X (25 February 2010);

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