Scheme for efficient fiber-based CARS probe

Mihaela Balu; Gangjun Liu; Zhongping Chen; Bruce J. Tromberg; Eric O. Potma

doi:10.1117/12.855187

26 February 2010 Scheme for efficient fiber-based CARS probe

Mihaela Balu, Gangjun Liu, Zhongping Chen, Bruce J. Tromberg, Eric O. Potma

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Proceedings Volume 7569, Multiphoton Microscopy in the Biomedical Sciences X; 75693A (2010) https://doi.org/10.1117/12.855187
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We demonstrate a fiber-based probe for maximum collection of the Coherent anti-Stokes Raman Scattering (CARS) signal in biological tissues. We discuss the design challenges including capturing the back-scattered forward generated CARS signal in the sample and the effects of fiber nonlinearities on the propagating pulses. Three different biological tissues were imaged in vitro in order to assess the performance of our fiberdelivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues.

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Mihaela Balu, Gangjun Liu, Zhongping Chen, Bruce J. Tromberg, and Eric O. Potma "Scheme for efficient fiber-based CARS probe", Proc. SPIE 7569, Multiphoton Microscopy in the Biomedical Sciences X, 75693A (26 February 2010); https://doi.org/10.1117/12.855187

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