25 February 2010 New scheme for polarimetric glucose sensing without polarizers
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Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A detection scheme involving amplitude modulation was simulated, demonstrating sensitivity to clinically relevant glucose concentrations and an acceptable error due to time varying linear birefringence of the cornea using Clarke Error Grid Analysis.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Amy M. Winkler, Amy M. Winkler, Garret T. Bonnema, Garret T. Bonnema, Jennifer K. Barton, Jennifer K. Barton, } "New scheme for polarimetric glucose sensing without polarizers", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757204 (25 February 2010); doi: 10.1117/12.842482; https://doi.org/10.1117/12.842482

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