26 February 2010 Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia
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Improved methods for detecting dysplasia, or pre-cancerous growth are a current clinical need, particularly in the esophagus. The currently accepted method of random biopsy and histological analysis provides only a limited examination of tissue in question while being coupled with a long time delay for diagnosis. Light scattering spectroscopy, in contrast, allows for inspection of the cellular structure and organization of tissue in vivo. Fourier-domain angle-resolved low-coherence interferometry (a/LCI) is a novel light scattering spectroscopy technique that provides quantitative depth-resolved morphological measurements of the size and optical density of the examined cell nuclei, which are characteristic biomarkers of dysplasia. Previously, clinical viability of the a/LCI system was demonstrated through analysis of ex vivo human esophageal tissue in Barrett's esophagus patients using a portable a/LCI, as was the development of a clinical a/LCI system. Data indicating the feasibility of the technique in other organ sites (colon, oral cavity) will be presented. We present an adaptation of the a/LCI system that will be used to investigate the presence of dysplasia in vivo in Barrett's esophagus patients.
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Neil G. Terry, Neil G. Terry, Yizheng Zhu, Yizheng Zhu, Adam Wax, Adam Wax, } "Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730P (26 February 2010); doi: 10.1117/12.842464; https://doi.org/10.1117/12.842464

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