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26 February 2010 High anisotropy utilized diffuse light suppression for large area spectroscopic imaging
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Abstract
A unique optical property of biological tissue is high anisotropy so that light is scattered in the same direction with respect to the incident direction. We demonstrate that simple back-directional gating allows us to take advantage of such an intrinsic property of biological tissue to significantly suppress unwanted diffuse light. In back-directional gated imaging, the high anisotropic property of the surrounding medium can serve as a waveguide in a moderate depth. Although this idea is straightforward, it has not been utilized for diffuse light suppression and imaging quality improvement such as contrast and resolution in large-area imaging for biological tissue. We further show that by combining a spectral analysis with back-directional gated imaging, image contrast and depth can be dramatically enhanced for visualizing stromal microvascular blood content in a relatively large area. Because microvasculature can be heterogeneous, our imaging approach can permit detailed visualization of microvascularity in a relatively large area up to ~20 mm x 20 mm.
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Zhengbin Xu, Jingjing Liu, and Young L. Kim "High anisotropy utilized diffuse light suppression for large area spectroscopic imaging", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730W (26 February 2010); https://doi.org/10.1117/12.841390
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