26 February 2010 Photon-cell interactive monte carlo (pciMC) model to describe both intracellular and extracellular optical pathways for biconcave red blood cells: phase function and albedo
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Abstract
A photon-cell interactive Monte Carlo ("pciMC") model was developed to quantify the intracellular optical propagation in a 3-dimensional biconcave red blood cell (RBC) model having a finite volume and intracellular hemoglobin. The orientation of RBCs with respect to the incident photons was randomized to allow either extra- or intra-cellular propagation depending on the incident point and angles where the photon propagation at the plasma-cell interface was determined by the Snell's law and Fresnell's law. In this study, the photon propagation through single RBC using the pciMC was compared against the Henyey-Greenstein phase function. The absorption dependent intracellular optical path length was evaluated in comparison to Mie theory. Both results showed good agreement. The pciMC can contribute to photo-spectroscopy of blood and tissues by quantifying both extra- and intra-cellular optical propagation.
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D. Sakota, S. Takatani, "Photon-cell interactive monte carlo (pciMC) model to describe both intracellular and extracellular optical pathways for biconcave red blood cells: phase function and albedo", Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 757316 (26 February 2010); doi: 10.1117/12.841780; https://doi.org/10.1117/12.841780
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