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12 February 2010Combined photothermal therapy and magneto-motive ultrasound imaging using multifunctional nanoparticles
Mohammad Mehrmohammadi,1 Li L. Ma,1 Yun-Sheng Chen,1 Min Qu,1 Pratixa Joshi,1 Raeanna M. Chen,1 Keith P. Johnston,1 Stanislav Emelianovhttps://orcid.org/0000-0002-7098-133X1
Photothermal therapy is a laser-based non-invasive technique for cancer treatment. Photothermal therapy can be
enhanced by employing metal nanoparticles that absorb the radiant energy from the laser leading to localized thermal
damages. Targeting of nanoparticles leads to more efficient uptake and localization of photoabsorbers thus increasing the
effectiveness of the treatment. Moreover, efficient targeting can reduce the required dosage of photoabsorbers; thereby
reducing the side effects associated with general systematic administration of nanoparticles. Magnetic nanoparticles, due
to their small size and response to an external magnetic field gradient have been proposed for targeted drug delivery. In
this study, we investigate the applicability of multifunctional nanoparticles (e.g., magneto-plasmonic nanoparticles) and
magneto-motive ultrasound imaging for image-guided photothermal therapy. Magneto-motive ultrasound imaging is an
ultrasound based imaging technique capable of detecting magnetic nanoparticles indirectly by utilizing a high strength
magnetic field to induce motion within the magnetically labeled tissue. The ultrasound imaging is used to detect the
internal tissue motion. Due to presence of the magnetic component, the proposed multifunctional nanoparticles along
with magneto-motive ultrasound imaging can be used to detect the presence of the photo absorbers. Clearly the higher
concentration of magnetic carriers leads to a monotonic increase in magneto-motive ultrasound signal. Thus, magnetomotive
ultrasound can determine the presence of the hybrid agents and provide information about their location and
concentration. Furthermore, the magneto-motive ultrasound signal can indicate the change in tissue elasticity - a
parameter that is expected to change significantly during the photothermal therapy. Therefore, a comprehensive guidance
and assessment of the photothermal therapy may be feasible through magneto-motive ultrasound imaging and magnetoplasmonic
nanoparticles.
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Mohammad Mehrmohammadi, Li L. Ma, Yun-Sheng Chen, Min Qu, Pratixa Joshi, Raeanna M. Chen, Keith P. Johnston, Stanislav Emelianov, "Combined photothermal therapy and magneto-motive ultrasound imaging using multifunctional nanoparticles," Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 757405 (12 February 2010); https://doi.org/10.1117/12.843055