17 February 2010 Synthesis and surface modification of highly fluorescent gold nanoclusters and their exploitation for cellular labeling
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Abstract
We introduce a general approach to make colorful fluorescent gold nanoclusters which are protected by dihydrolipoic acid, mercaptoundecanoic acid and polyethylenimine. The fluorescent gold nanoclusters can perform a variety of bioconjugation processes such as PEGylation, biotinylation as well as forming complex nanobioconjugates with streptavidins. The brightening effects under proper surface modification are also reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Nonspecific uptake by human aortic endothelial cells is demonstrated.
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Cheng-An J. Lin, Cheng-An J. Lin, Chih-Hsien Lee, Chih-Hsien Lee, Jiun-Tai Hsieh, Jiun-Tai Hsieh, Wan-Chun Yu, Wan-Chun Yu, Hong-Zhi Yang, Hong-Zhi Yang, Jimmy K. Li, Jimmy K. Li, Ralph Sperling, Ralph Sperling, Hsueh-Hsiao Wang, Hsueh-Hsiao Wang, Hung-I Yeh, Hung-I Yeh, Wolfgang J. Parak, Wolfgang J. Parak, Walter H. Chang, Walter H. Chang, } "Synthesis and surface modification of highly fluorescent gold nanoclusters and their exploitation for cellular labeling", Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 757506 (17 February 2010); doi: 10.1117/12.841540; https://doi.org/10.1117/12.841540
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