17 February 2010 Synthesis and surface modification of highly fluorescent gold nanoclusters and their exploitation for cellular labeling
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Abstract
We introduce a general approach to make colorful fluorescent gold nanoclusters which are protected by dihydrolipoic acid, mercaptoundecanoic acid and polyethylenimine. The fluorescent gold nanoclusters can perform a variety of bioconjugation processes such as PEGylation, biotinylation as well as forming complex nanobioconjugates with streptavidins. The brightening effects under proper surface modification are also reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Nonspecific uptake by human aortic endothelial cells is demonstrated.
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Cheng-An J. Lin, Cheng-An J. Lin, Chih-Hsien Lee, Chih-Hsien Lee, Jiun-Tai Hsieh, Jiun-Tai Hsieh, Wan-Chun Yu, Wan-Chun Yu, Hong-Zhi Yang, Hong-Zhi Yang, Jimmy K. Li, Jimmy K. Li, Ralph Sperling, Ralph Sperling, Hsueh-Hsiao Wang, Hsueh-Hsiao Wang, Hung-I Yeh, Hung-I Yeh, Wolfgang J. Parak, Wolfgang J. Parak, Walter H. Chang, Walter H. Chang, "Synthesis and surface modification of highly fluorescent gold nanoclusters and their exploitation for cellular labeling", Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 757506 (17 February 2010); doi: 10.1117/12.841540; https://doi.org/10.1117/12.841540
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