17 February 2010 Cellular uptake of conjugated InP quantum dots
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Abstract
Indium phosphide (InP) nanocrystals show similar absorbance and emission spectra to CdTe quantum dots, but unlike particles containing cadmium, may potentially be used in in vivo applications. However, the particles are more challenging to make water-soluble, show broader emission spectra than most quantum dots, and their behavior in living cells is largely unknown. In this work we solubilize InP nanocrystals with simple thiols (mercaptopropionic acid) and conjugate them to the neurotransmitter dopamine or the protein transferrin. Degree of uptake and labeling patterns of QDs alone, QD-dopamine, and QD-transferrin are compared in different cell lines and toxicity is evaluated using the sulforhodamine B (SRB) assay.
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Hicham Chibli, Hicham Chibli, Lina Carlini, Lina Carlini, Kalonji Ntumba, Kalonji Ntumba, Jay Nadeau, Jay Nadeau, } "Cellular uptake of conjugated InP quantum dots", Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 75750T (17 February 2010); doi: 10.1117/12.848942; https://doi.org/10.1117/12.848942
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