11 March 2010 Applications of terahertz-pulsed technology in the pharmaceutical industry
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Proceedings Volume 7601, Terahertz Technology and Applications III; 760102 (2010); doi: 10.1117/12.840844
Event: SPIE OPTO, 2010, San Francisco, California, United States
Abstract
Coatings are applied to pharmaceutical tablets (or pills) to for either cosmetic or release control reasons. Cosmetic coatings control the colour or to mask the taste of an active ingredient; the thickness of these coating is not critical to the performance of the product. On the other hand the thickness and uniformity of a controlled release coating has been found affect the release of the active ingredient. In this work we have obtained from a pharmacy single brand of pantoprazole tablet and mapped them using terahertz pulsed imaging (TPI) prior to additional dissolution testing. Three terahertz parameters were derived for univariate analysis for each layer: coating thickness, terahertz electric field peak strength and terahertz interface index. These parameters were then correlated dissolution tested. The best fit was found to be with combined coating layer thickness of the inert layer and enteric coating. The commercial tablets showed a large variation in coating thickness.
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Philip F. Taday, "Applications of terahertz-pulsed technology in the pharmaceutical industry", Proc. SPIE 7601, Terahertz Technology and Applications III, 760102 (11 March 2010); doi: 10.1117/12.840844; https://doi.org/10.1117/12.840844
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KEYWORDS
Tablets

Absorbance

Spectroscopy

Interfaces

Pharmacy

Raman spectroscopy

Reflection

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