22 January 2010 Infrared laser-based sensing in medical applications
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Laser-spectroscopic applications in medicine increase in importance. We present two medical applications of laser-based analyses of trace gases. The analysis of exhaled breath concerns the determination of the D/H isotope ratio after intake of a small amount of heavy water. The D/H isotope ratio can be used to deduce the total body water weight and lays the foundation for many other laser-based clinical applications. An elevated D/H ratio could be monitored in breath samples up to 30 days after ingestion of only 5 ml of D2O. A second example concerns the analysis of surgical smoke produced in minimally invasive laparoscopic surgery with electroknives. The quantitative determination of harmless and hazardous compounds down to the ppm level is demonstrated. A specific example is the presence of sevoflurane at concentrations of 80 to 300 ppm, an anesthetic, which to our knowledge is measured for the first time in an abdominal cavity.
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Markus W. Sigrist, Markus W. Sigrist, Richard Bartlome, Richard Bartlome, Michele Gianella, Michele Gianella, } "Infrared laser-based sensing in medical applications", Proc. SPIE 7608, Quantum Sensing and Nanophotonic Devices VII, 760808 (22 January 2010); doi: 10.1117/12.839595; https://doi.org/10.1117/12.839595

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