Imaging the basic function unit of small/medium animal via diagnostic CT with an adaptor-and-holder assembly (AAHA): feasibility study

Xiangyang Tang

doi:10.1117/12.840242

22 March 2010 Imaging the basic function unit of small/medium animal via diagnostic CT with an adaptor-and-holder assembly (AAHA): feasibility study

Xiangyang Tang

Author Affiliations +

Proceedings Volume 7622, Medical Imaging 2010: Physics of Medical Imaging; 76222Y (2010) https://doi.org/10.1117/12.840242
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Imaging the basic functional unit (BFU) of small/medium animal - an organ's smallest assembly of diverse cells that functions like the organ itself - is of significance in pre-clinical research. A BFU is usually a spheroid with its horizontal, transverse and vertical radii equal to ~50 μm and its dimension is virtually the same in small/medium animal and human. Apparently, state-of-the-art diagnostic CT scanners can't image the BFU of small/medium animal directly because of its insufficient spatial resolution. Micro-CT is of sufficient spatial resolution, but its contrast, temporal and spectral resolutions are inferior to its counterparts of diagnostic CT. We propose to image the basic function unit of small/medium animal using diagnostic CT with an adaptor-and-holder assembly (AAHA). In data acquisition, the adaptor rotates in phase with x-ray source, but the animal holder spins at an angular velocity that is opposite to the direction of adaptor rotation. Consequently, the pose of the animal remains unchanged in data acquisition, which can reduce animal's visceral motion substantially. With such an AAHA device, the spatial resolution can be increased more than 2.5 times, while the temporal resolution can potentially be increased 2 times if super-short scan is exercised. In practice, the AAHA device may not align perfectly and rotate rigorously in phase with x-ray source. Hence, motioncompensated reconstruction is needed. With a preliminary evaluation conducted in the feasibility study, it is believed that, a diagnostic CT with the AAHA device may enable imaging small/medium animal at superior spatiotemporal and contrast resolution in comparison to micro-CT.

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Xiangyang Tang "Imaging the basic function unit of small/medium animal via diagnostic CT with an adaptor-and-holder assembly (AAHA): feasibility study", Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 76222Y (22 March 2010); https://doi.org/10.1117/12.840242

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KEYWORDS

Diagnostics

X-ray computed tomography

Data acquisition

Sensors

Spatial resolution

Temporal resolution

Computed tomography

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