12 March 2010 Directional assessment of fiber integrity in Q-ball imaging
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Q-ball imaging (QBI) is a diffusion imaging technique that provides unique microstructural information and outperforms diffusion tensor imaging (DTI) in areas of fiber crossings. The generalized fractional anisotropy (GFA) is a widely accepted quantitative measure of fiber integrity for QBI. In this paper we demonstrate a major drawback of the GFA occuring in crossing fiber regions: the fiber integrity is heavily underestimated here. We present a new, directional anisotropy measure and compare it to the GFA using custom-designed fiber phantoms and Monte Carlo simulations. Furthermore, we present in-vivo data of the measure. With the expense of reduced CNR, the new measure allows a better quantification of fiber bundles in crossing regions and potentially yields additional information regarding non-dominant tracts within a voxel.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Klaus H. Fritzsche, Klaus H. Fritzsche, Frederik B. Laun, Frederik B. Laun, Bram Stieltjes, Bram Stieltjes, Hans-Peter Meinzer, Hans-Peter Meinzer, } "Directional assessment of fiber integrity in Q-ball imaging", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76231G (12 March 2010); doi: 10.1117/12.839608; https://doi.org/10.1117/12.839608

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