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12 March 2010 Improving fluid registration through white matter segmentation in a twin study design
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Robust and automatic non-rigid registration depends on many parameters that have not yet been systematically explored. Here we determined how tissue classification influences non-linear fluid registration of brain MRI. Twin data is ideal for studying this question, as volumetric correlations between corresponding brain regions that are under genetic control should be higher in monozygotic twins (MZ) who share 100% of their genes when compared to dizygotic twins (DZ) who share half their genes on average. When these substructure volumes are quantified using tensor-based morphometry, improved registration can be defined based on which method gives higher MZ twin correlations when compared to DZs, as registration errors tend to deplete these correlations. In a study of 92 subjects, higher effect sizes were found in cumulative distribution functions derived from statistical maps when performing tissue classification before fluid registration, versus fluidly registering the raw images. This gives empirical evidence in favor of pre-segmenting images for tensor-based morphometry.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yi-Yu Chou, Natasha Lepore, Caroline Brun, Marina Barysheva, Katie McMahon, Greig I. de Zubicaray, Margaret J. Wright, Arthur W. Toga, and Paul M. Thompson "Improving fluid registration through white matter segmentation in a twin study design", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76232X (12 March 2010);

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