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9 March 2010 Vertical cup-to-disc ratio measurement for diagnosis of glaucoma on fundus images
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Glaucoma is a leading cause of permanent blindness. Retinal fundus image examination is useful for early detection of glaucoma. In order to evaluate the presence of glaucoma, the ophthalmologists determine the cup and disc areas and they diagnose glaucoma using a vertical cup-to-disc ratio. However, determination of the cup area is very difficult, thus we propose a method to measure the cup-to-disc ratio using a vertical profile on the optic disc. First, the blood vessels were erased from the image and then the edge of optic disc was then detected by use of a canny edge detection filter. Twenty profiles were then obtained around the center of the optic disc in the vertical direction on blue channel of the color image, and the profile was smoothed by averaging these profiles. After that, the edge of the cup area on the vertical profile was determined by thresholding technique. Lastly, the vertical cup-to-disc ratio was calculated. Using seventy nine images, including twenty five glaucoma images, the sensitivity of 80% and a specificity of 85% were achieved with this method. These results indicated that this method can be useful for the analysis of the optic disc in glaucoma examinations.
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Yuji Hatanaka, Atsushi Noudo, Chisako Muramatsu, Akira Sawada, Takeshi Hara, Tetsuya Yamamoto, and Hiroshi Fujita "Vertical cup-to-disc ratio measurement for diagnosis of glaucoma on fundus images", Proc. SPIE 7624, Medical Imaging 2010: Computer-Aided Diagnosis, 76243C (9 March 2010);

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