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23 February 2010 Correlation of hemodynamic forces and atherosclerotic plaque components
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Local hemodynamic forces in atherosclerotic carotid arteries are thought to trigger cellular and molecular mechanisms that determine plaque vulnerability. Magnetic Resonance Imaging (MRI) has emerged as a powerful tool to characterize human carotid atherosclerotic plaque composition and morphology, and to identify plaque features shown to be key determinants of plaque vulnerability. Image-based computational fluid dynamics (CFD) has allowed researchers to obtain time-resolved wall shear stress (WSS) information for atherosclerotic carotid arteries. A deeper understanding of the mechanisms of initiation and progression of atherosclerosis can be obtained through the comparison of WSS and plaque composition. The aim of this study was to explore the hypothesis that intra-plaque hemorrhage, a feature associated with adverse outcomes and plaque progression, is more likely to occur in plaques with elevated WSS levels. We compared 2D representations of the WSS distribution and the amount of intra-plaque hemorrhage to determine relationships between WSS patterns and plaque vulnerability. We extracted WSS data to compare patterns between cases with and without hemorrhage. We found elevated values of WSS at regions where intra-plaque hemorrhage was detected, suggesting that WSS might be used as a marker for the risk of intra-plaque hemorrhage and subsequent complications.
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Gádór Canton, Bernard Chiu, Chun Yuan, and William S. Kerwin "Correlation of hemodynamic forces and atherosclerotic plaque components", Proc. SPIE 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 76250G (23 February 2010); doi: 10.1117/12.844296;

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