23 February 2010 Biomechanical based image registration for head and neck radiation treatment
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Deformable image registration of four head and neck cancer patients was conducted using biomechanical based model. Patient specific 3D finite element models have been developed using CT and cone beam CT image data of the planning and a radiation treatment session. The model consists of seven vertebrae (C1 to C7), mandible, larynx, left and right parotid glands, tumor and body. Different combinations of boundary conditions are applied in the model in order to find the configuration with a minimum registration error. Each vertebra in the planning session is individually aligned with its correspondence in the treatment session. Rigid alignment is used for each individual vertebra and to the mandible since deformation is not expected in the bones. In addition, the effect of morphological differences in external body between the two image sessions is investigated. The accuracy of the registration is evaluated using the tumor, and left and right parotid glands by comparing the calculated Dice similarity index of these structures following deformation in relation to their true surface defined in the image of the second session. The registration improves when the vertebrae and mandible are aligned in the two sessions with the highest Dice index of 0.86±0.08, 0.84±0.11, and 0.89±0.04 for the tumor, left and right parotid glands, respectively. The accuracy of the center of mass location of tumor and parotid glands is also improved by deformable image registration where the error in the tumor and parotid glands decreases from 4.0±1.1, 3.4±1.5, and 3.8±0.9 mm using rigid registration to 2.3±1.0, 2.5±0.8 and 2.0±0.9 mm in the deformable image registration when alignment of vertebrae and mandible is conducted in addition to the surface projection of the body.
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Adil Al-Mayah, Adil Al-Mayah, Joanne Moseley, Joanne Moseley, Shannon Hunter, Shannon Hunter, Mike Velec, Mike Velec, Lily Chau, Lily Chau, Stephen Breen, Stephen Breen, Kristy Brock, Kristy Brock, } "Biomechanical based image registration for head and neck radiation treatment", Proc. SPIE 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 76250M (23 February 2010); doi: 10.1117/12.845256; https://doi.org/10.1117/12.845256

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