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9 March 2010 Magnetic resonance imaging for white matter degradation in fornix following mild traumatic brain injury
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Abstract
The alterations of the fornix in mild traumatic brain injury (mTBI) were investigated using diffusion tensor imaging (DTI) and T1-weighetd anatomical imaging. The primary goal of this study was to test that hypothesis that the fornix might play a major role in the memory and learning dysfunctions in the post-concussion syndrome, which may related to the white matter (WM) degradations following mild traumatic brain injury. N=24 mTBI patients were longitudinally studied in two time points with 6-month intervals using a 4-Tesla MRI scanner to measure the WM integrity of fornix and the fornix-to-brain ratio (FBR), and compared with matched healthy controls. Our data show that the WM degradation in fornix onset in the acute stage after mild TBI when the post-injury time was less than 6 weeks, and that this WM degradation continued during the following 6-month period of recovery. In summary, using DTI and structural MRI together can effectively detect the fornix changes in both cross-sectional and longitudinal investigations. Further studies are warranted to exam the association between the fornix alterations and neurocognitive performance of TBI patients.
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Wang Zhan, Lauren Boreta, and Grant Gauger "Magnetic resonance imaging for white matter degradation in fornix following mild traumatic brain injury", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 762608 (9 March 2010); https://doi.org/10.1117/12.845470
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