Understanding bone remodeling and mechanical property characteristics is important for assessing treatments to
accelerate healing or in developing diagnostics to evaluate successful return to function. The murine system whereby
mid-diaphaseal tibia fractures are imparted on the subject and fracture healing is assessed at different time points and
under different therapeutic conditions is a particularly useful model to study. In this work, a novel inverse geometric
nonlinear elasticity modeling framework is proposed that can reconstruct multiple mechanical properties from uniaxial
testing data. To test this framework, the Lame' constants were reconstructed within the context of a murine cohort (n=6)
where there were no differences in treatment post tibia fracture except that half of the mice were allowed to heal 4 days
longer (10 day, and 14 day healing time point, respectively). The properties reconstructed were a shear modulus of
G=511.2 ± 295.6 kPa, and 833.3± 352.3 kPa for the 10 day, and 14 day time points respectively. The second Lame'
constant reconstructed at λ=1002.9 ±42.9 kPa, and 14893.7 ± 863.3 kPa for the 10 day, and 14 day time points
respectively. An unpaired Student t-test was used to test for statistically significant differences among the groups. While
the shear modulus did not meet our criteria for significance, the second Lame' constant did at a value p<0.0001.
Traditional metrics that are commonly used within the bone fracture healing research community were not found to be