9 March 2010 Simultaneous measures of kinematics and fMRI: relation between movement parameters and activation maps in healthy subjects
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Abstract
The objective of this study was to identify on healthy subjects the correlation between motor performances and brain activation maps, by the simultaneous use of functional magnetic resonance imaging (fMRI) and optoelectronic motion analysis system. The specific goal was to individuate how amplitude affects the related cerebral flow maps in active, passive and electrical stimulated (FES) movements. Ankle DorsiFlexion (ADF) was chosen as analyzed task because of its importance in the gait cycle. Firstly FES compatibility with fMRI images acquisition was assessed, both for the safety of the subject and of the device, and for mutual disturbances evaluation. We identified the experimental protocol so as to optimize the measured cerebral maps and the repeatability of the results. Intra-subject analysis of movement parameters along with brain activation mapping was performed. First level analysis to compare different execution modalities have been studied and preliminary qualitative results are reported. The long term application is the exploitation of the combined system in the evaluation of neurological patients where the definition of the motor tasks could be only partially accomplished depending on the patient residual functionality.
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M. Gandolla, C. Casellato, S. Ferrante, G. Ferrigno, G. Baselli, F. Molteni, A. Martegani, T. Frattini, A. Pedrocchi, "Simultaneous measures of kinematics and fMRI: relation between movement parameters and activation maps in healthy subjects", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 76261U (9 March 2010); doi: 10.1117/12.837014; https://doi.org/10.1117/12.837014
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