Regional homogeneity changes in prelingually deafened patients: a resting-state fMRI study

Wenjing Li; Huiguang He; Junfang Xian; Bin Lv; Meng Li; Yong Li; Zhaohui Liu; Zhenchang Wang

doi:10.1117/12.844105

9 March 2010 Regional homogeneity changes in prelingually deafened patients: a resting-state fMRI study

Wenjing Li, Huiguang He, Junfang Xian, Bin Lv, Meng Li, Yong Li, Zhaohui Liu, Zhenchang Wang

Proceedings Volume 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging; 76261V (2010) https://doi.org/10.1117/12.844105
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Resting-state functional magnetic resonance imaging (fMRI) is a technique that measures the intrinsic function of brain and has some advantages over task-induced fMRI. Regional homogeneity (ReHo) assesses the similarity of the time series of a given voxel with its nearest neighbors on a voxel-by-voxel basis, which reflects the temporal homogeneity of the regional BOLD signal. In the present study, we used the resting state fMRI data to investigate the ReHo changes of the whole brain in the prelingually deafened patients relative to normal controls. 18 deaf patients and 22 healthy subjects were scanned. Kendall's coefficient of concordance (KCC) was calculated to measure the degree of regional coherence of fMRI time courses. We found that regional coherence significantly decreased in the left frontal lobe, bilateral temporal lobes and right thalamus, and increased in the postcentral gyrus, cingulate gyrus, left temporal lobe, left thalamus and cerebellum in deaf patients compared with controls. These results show that the prelingually deafened patients have higher degree of regional coherence in the paleocortex, and lower degree in neocortex. Since neocortex plays an important role in the development of auditory, these evidences may suggest that the deaf persons reorganize the paleocortex to offset the loss of auditory.

Citation Download Citation

Wenjing Li, Huiguang He, Junfang Xian, Bin Lv, Meng Li, Yong Li, Zhaohui Liu, and Zhenchang Wang "Regional homogeneity changes in prelingually deafened patients: a resting-state fMRI study", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 76261V (9 March 2010); https://doi.org/10.1117/12.844105

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KEYWORDS

Control systems

Functional magnetic resonance imaging

Brain

Thalamus

Cerebellum

Brain mapping

Head

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