12 March 2010 Detecting breast microcalcifications using super-resolution and wave-equation ultrasound imaging: a numerical phantom study
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Ultrasound image resolution and quality need to be significantly improved for breast microcalcification detection. Super-resolution imaging with the factorization method has recently been developed as a promising tool to break through the resolution limit of conventional imaging. In addition, wave-equation reflection imaging has become an effective method to reduce image speckles by properly handling ultrasound scattering/diffraction from breast heterogeneities during image reconstruction. We explore the capabilities of a novel super-resolution ultrasound imaging method and a wave-equation reflection imaging scheme for detecting breast microcalcifications. Super-resolution imaging uses the singular value decomposition and a factorization scheme to achieve an image resolution that is not possible for conventional ultrasound imaging. Wave-equation reflection imaging employs a solution to the acoustic-wave equation in heterogeneous media to backpropagate ultrasound scattering/diffraction waves to scatters and reconstruct images of heterogeneities. We construct numerical breast phantoms using in vivo breast images, and use a finite-difference wave-equation scheme to generate ultrasound data scattered from inclusions that mimic microcalcifications. We demonstrate that microcalcifications can be detected at full spatial resolution using the super-resolution ultrasound imaging and wave-equation reflection imaging methods.
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Lianjie Huang, Lianjie Huang, Francesco Simonetti, Francesco Simonetti, Peter Huthwaite, Peter Huthwaite, Robert Rosenberg, Robert Rosenberg, Michael Williamson, Michael Williamson, } "Detecting breast microcalcifications using super-resolution and wave-equation ultrasound imaging: a numerical phantom study", Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762919 (12 March 2010); doi: 10.1117/12.844459; https://doi.org/10.1117/12.844459

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