22 October 2010 Novel reflectivity-difference biosensor
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The traditional immobilized biomolecule detection technique on arrays has been fluorescence, but this has limitations because of its reliance on fluorophores. Alternatively, many label-free detection techniques have been developed such as surface plasmon resonance (SPR), ellipsometry, thin-film interference, diffractometry, and waveguides. These techniques have the advantage of high speed and high sensitivity, but in exchange rely on complicated structures or detailed sensing cells. A novel reflectivity-difference biosensor is introduced in this paper. When the sensor covered with a protein layer, the cells and the land would have opposite changes of the reflectance which lead to intensity shifts at the far-field diffraction plane. Therefore, it is convenient for the operation without intricate sensor structures and multifarious optical systems.
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Han Chen, Han Chen, Lian Wei, Lian Wei, Ying Feng, Ying Feng, "Novel reflectivity-difference biosensor", Proc. SPIE 7658, 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optoelectronic Materials and Devices for Detector, Imager, Display, and Energy Conversion Technology, 76583G (22 October 2010); doi: 10.1117/12.865233; https://doi.org/10.1117/12.865233

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