5 May 2010 Quantum dots in life sciences: applications, benefits, and safety issues
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Luminescent semiconductor quantum dots (QDs) possess several unique optical and spectroscopic properties including high quantum yields, broad absorption spectra coupled to narrow symmetric, size-tunable emissions allowing large achievable Stokes shifts, and exceptional resistance to photo- and chemical degradation. These properties make QDs unique enabling materials for the development of the next generation of highly efficient biosensors for health security applications, particularly within the context of living and fixed cells. Paramount in this developmental process is addressing the biocompatibility of the QD materials. We are developing robust and facile delivery schemes for the selective intracellular delivery of QD-based nanoassemblies. These schemes are based upon the self-assembly and subsequent cellular uptake of QD-peptide and QD-polymer bioconjugates. Cellular delivery experiments utilizing both delivery schemes will be presented. The advantages and disadvantages of each approach will be discussed, including the intracellular fate and stability of the QD-nanoassemblies.
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James B. Delehanty, James B. Delehanty, Christopher E. Bradburne, Christopher E. Bradburne, Kelly Boeneman, Kelly Boeneman, Kimihiro Susumu, Kimihiro Susumu, Bing C. Mei, Bing C. Mei, Juan B. Blanco-Canosa, Juan B. Blanco-Canosa, Phillip E. Dawson, Phillip E. Dawson, Hedi Mattoussi, Hedi Mattoussi, Alan Huston, Alan Huston, Igor L. Medintz, Igor L. Medintz, "Quantum dots in life sciences: applications, benefits, and safety issues", Proc. SPIE 7666, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IX, 766619 (5 May 2010); doi: 10.1117/12.853121; https://doi.org/10.1117/12.853121

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