5 May 2010 Experimental demonstration of lossy recording of information into DNA
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Non-coding DNA comprises the majority of an organism's DNA and has the potential to store massive amounts of information. We hypothesize that information can be stored into non-coding DNA using a noisy mechanism comprised of thermally sensitive liposomes as sensors and measuring transport state variable information through DNA release and binding in response to stimuli. To test our hypothesis, we performed experiments that demonstrated the in situ, de novo synthesis of information-encoding DNA using natural biomaterials. Our results were compared to a lumped-parameter model designed to simulate the experiments. We found promising correlation between the DNA sequences generated by the simulations and those generated experimentally, suggesting that the in situ, de novo synthesized DNA does store recoverable information by the mechanism proposed.
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Maria E. Tanner, Maria E. Tanner, Elizabeth A. Vasievich, Elizabeth A. Vasievich, Jonathan M. Protz, Jonathan M. Protz, } "Experimental demonstration of lossy recording of information into DNA", Proc. SPIE 7679, Micro- and Nanotechnology Sensors, Systems, and Applications II, 76792O (5 May 2010); doi: 10.1117/12.858775; https://doi.org/10.1117/12.858775

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