29 April 2010 Functional diffuse reflectance spectroscopy at small source-detector distances based on fast-gated single-photon avalanche diodes
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Abstract
In this review we present the instrumental and theoretical developments for functional diffuse reflectance spectroscopy at small source-detector distances. We proposed the possibility to perform photon migration measurements at null or small inter-fiber distances demonstrating the improvement of this novel approach in terms of achievable contrast, spatial resolution and number of detected photons. We developed a novel system to perform time-resolved diffuse reflectance measurement at small source detector separation based on a single photon avalanche photodiode (SPAD) operated in fast time gated mode and a broadband fiber laser. By means of time gating it is possible to detect longer lived photons neglecting initial ones. We show results both on homogeneous and inhomogeneous tissue phantoms demonstrating a dynamic range of 7 orders of magnitude and a temporal range of 6 nanoseconds. Furthermore, this approach proved valuable to detect brain activity.
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Davide Contini, Davide Contini, Antonio Pifferi, Antonio Pifferi, Lorenzo Spinelli, Lorenzo Spinelli, Alessandro Torricelli, Alessandro Torricelli, Rinaldo Cubeddu, Rinaldo Cubeddu, Fabrizio Martelli, Fabrizio Martelli, Giovanni Zaccanti, Giovanni Zaccanti, Alberto Dalla Mora, Alberto Dalla Mora, Alberto Tosi, Alberto Tosi, Franco Zappa, Franco Zappa, Sergio Cova, Sergio Cova, } "Functional diffuse reflectance spectroscopy at small source-detector distances based on fast-gated single-photon avalanche diodes", Proc. SPIE 7681, Advanced Photon Counting Techniques IV, 768102 (29 April 2010); doi: 10.1117/12.852557; https://doi.org/10.1117/12.852557
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