21 April 2010 Photonic materials for encoding and detection of biomolecules
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Multiplex assays have attracted considerable interest to meet the growing demand for clinical diagnosis, gene expression, drug discovery, and so on. Most of the assays are based on molecular binding or recognition events. In this point, different probe biomolecules could be immobilized to encoded carriers, which can be mixed and subjected to an assay simultaneously and then many binding events can be distinguished by their codes. Herein we summarize our work on photonic beads as novel encoded carriers of biomolecules in multiplex bioassays. We have successfully fabricated different kinds of encoded photonic beads with controlled size and monodispersity by microfluidic device. The beads with opal structure and inverse opal structure could be used in multiplex labeling detection and label-free detection of biomolecules, respectively. These photonic beads provide a new coding strategy of suspension array for low cost, sensitive and simultaneous multiplex bioassay.
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Yuanjin Zhao, Yuanjin Zhao, Xiangwei Zhao, Xiangwei Zhao, Zhongze Gu, Zhongze Gu, "Photonic materials for encoding and detection of biomolecules", Proc. SPIE 7682, Photonic Microdevices/Microstructures for Sensing II, 768203 (21 April 2010); doi: 10.1117/12.850964; https://doi.org/10.1117/12.850964

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