28 April 2010 Ultra-sensitive label-free biosensing by using single-mode coupled microcavity laser
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We report that by using a single mode coupled microcavity laser, we successfully realized a sensitivity of 80 pg/ml for detecting BSA. The detecting scheme also works for other bio samples. The result proves that active sensing with microcavity laser can achieve ultrahigh sensitivity. Further analysis shows that the ultra-sensitivity comes from the slight change of coupling coefficient between the two coupled microcavities.
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Lei Xu, Lei Xu, Hao Li, Hao Li, Xiang Wu, Xiang Wu, Lei Shang, Lei Shang, Liying Liu, Liying Liu, "Ultra-sensitive label-free biosensing by using single-mode coupled microcavity laser", Proc. SPIE 7682, Photonic Microdevices/Microstructures for Sensing II, 76820C (28 April 2010); doi: 10.1117/12.853331; https://doi.org/10.1117/12.853331


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