Analysis of the brain as a physical system, that has the capacity of generating a display of every
day observed experiences and contains some knowledge of the physical reality which stimulates those
experiences, suggests the brain executes a self-measurement process described by quantum theory.
Assuming physical reality is a universe of interacting self-measurement loops, we present a model of space
as a field of cells executing such self-measurement activities. Empty space is the observable associated
with the measurement of this field when the mass and charge density defining the material aspect of the
cells satisfy the least action principle. Content is the observable associated with the measurement of the
quantum wave function ψ interpreted as mass-charge displacements. The illusion of space and its content
incorporated into cognitive biological systems is evidence of self-measurement activity that can be
associated with quantum operations.