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18 May 2010Monitoring of the vessel capillary density spatial pattern in epithelium phantom model
Monitoring of the vessel capillary density and blood oxygenation spatial pattern in epithelium is important for shock
detection and it's preventing interventions. The challenge is the complex epithelium structure, absorption and scattering
of light in the multiple tissue layers. In this paper we describe results of estimating the vessel capillary density pattern in
tissue phantoms collecting spatially resolved reflectance spectra. We designed tissue phantom which mimics optical
properties of epithelium including microvasculature. Grids grooved in the phantom plates mimicking the blood capillary
network containing freshly prepared oxy-hemoglobin solution. The preliminary results shows that the new method can
reasonably extracts minor spatial deviations of oxygenation and local volume blood fraction - parameters, directly related
to the local vessel density patterns.
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Rajesh Kanawade, Gennadiy Saiko, Alexandre Douplik, "Monitoring of the vessel capillary density spatial pattern in epithelium phantom model," Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 771526 (18 May 2010); https://doi.org/10.1117/12.854450