18 May 2010 Effect of light scattering superficial layer on the accuracy of flow velocity profiles measurements by Doppler optical coherence tomography
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Abstract
Doppler Optical Coherence Tomography (DOCT) is a modern technique used for accurate measurements of blood flow in the superficial layers of human skin, retina or other tissues and their phantoms. In this work, we considered the effect of both static and dynamic superficial layer of the scattering medium on the measured velocity of a flow located beneath this layer. In the case of static layer a tissue phantom consisting of a plain glass capillary (inner size 0.3 × 3 mm) embedded into a slab of Intralipid solution mimicking human skin was designed. Flow velocity profiles were measured at different embedding depths and Intralipid concentrations. The obtained results show a decrease in the measured peak velocity value of the flow in the embedded capillary with increasing the embedding depth and/or concentration of the Intralipid solution in the static layer. A dynamic superficial layer was considered in the case with two plain glass capillaries (inner size 0.2 × 2 mm) attached together. Flow rate of the lower capillary was fixed to 100 ml/h, while the parameters of the upper flow were varied (concentration from 1 % to 4 % and flow rate from 0 to 200 ml/h). The results obtained with the above parameters do not show significant distortions in the measured flow velocity profile, only false velocity peaks arising at the rear flow boundaries.
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J. Lauri, J. Lauri, Alexander V. Bykov, Alexander V. Bykov, Alexander V. Priezzhev, Alexander V. Priezzhev, R. Myllylä, R. Myllylä, } "Effect of light scattering superficial layer on the accuracy of flow velocity profiles measurements by Doppler optical coherence tomography", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77152L (18 May 2010); doi: 10.1117/12.854223; https://doi.org/10.1117/12.854223
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