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18 May 2010Implantable reflectance pulse transit time blood pressure sensor with oximetry capability
We present a novel implantable multi-wavelength reflectance sensor for the measurement of blood pressure with
pulse transit time (PTT). Continuous long-term monitoring of blood pressure and arterial oxygen saturation is
vital for medical diagnostics and the ensuing therapy of cardiovascular diseases. Conventional cuff-based blood
pressure monitors do not provide continuous data and put severe constraints on the patients' daily lives. An
implantable sensor would eliminate such problems. The new biocompatible sensor is placed subcutaneously on
blood perfused tissue. The PTT is calculated by photoplethysmograms and the ECG-signal, that is recorded with
intracorporal electrodes. In addition, the sensor detects the arterial oxygen saturation. An ensuing spectralphotometric
analysis of the light intensity changes delivers data on the concentration of dysfunctional hemoglobin
derivatives. Experimental measurements showed a clear correlation between the estimated PTT and the systolic
blood pressure reference. These initial results demonstrate the potential of the sensor as part of an fully
implantable sensor system for the longterm-monitoring of cardiovascular parameters.
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J. Fiala, R. Gehrke, M. Theodor, P. Bingger, K. Förster, C. Heilmann, F. Beyersdorf, H. Zappe, A. Seifert, "Implantable reflectance pulse transit time blood pressure sensor with oximetry capability," Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77152Q (18 May 2010); https://doi.org/10.1117/12.854512