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18 May 2010 Multi-spectral mapping of in vivo skin hemoglobin and melanin
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Abstract
The multi-spectral imaging technique has been used for distant mapping of in-vivo skin chromophores by analyzing spectral data at each reflected image pixel and constructing 2-D maps of the relative concentrations of oxy-/deoxyhemoglobin and melanin. Instead of using a broad visible-NIR spectral range, this study focuses on narrowed spectral band 500-700 nm, so speeding-up the signal processing procedure. Regression analysis confirmed that superposition of three Gaussians is optimal analytic approximation for the oxy-hemoglobin absorption tabular spectrum in this spectral band, while superposition of two Gaussians fits well for deoxy-hemoglobin absorption and exponential function - for melanin absorption. The proposed approach was clinically tested for three types of in-vivo skin provocations - ultraviolet irradiance, chemical reaction with vinegar essence and finger arterial occlusion. Spectral range 500-700 nm provided better sensitivity to oxy-hemoglobin changes and higher response stability to melanin than two reduced ranges 500-600 nm and 530-620 nm.
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Dainis Jakovels, Janis Spigulis, and Inga Saknite "Multi-spectral mapping of in vivo skin hemoglobin and melanin", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77152Z (18 May 2010); https://doi.org/10.1117/12.853928
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