30 August 2010 Mechanistic studies into the Raman enhancement of enediol-semiconducting nanoparticle conjugates and their use in biological applications
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Abstract
Raman scattering enhancement was observed in systems where different metal oxide semiconductors (TiO2, Fe2O3, ZrO2 and CeO2) were modified with enediol ligands. The intensity of Raman scattering was dependent on laser frequency and correlated with the extinction coefficient of the charge-transfer complex of the enediol ligands and nanoparticles. The intensity and frequency of the Raman bands was found to depend on the chemical composition of the enediol ligand and the chemical composition (and crystallinity) of the nanoparticles. The intensity of the Raman signal depends on the number of surface binding sites, electron density of the ligands and their dipole moment. We also found that Raman scattering is observed for the bioconjugated system, where a peptide is linked to the surface of the particle through a catechol linker. These studies are important since these bioconjugates can be used to form the basis of Raman-based, in vitro and importantly in vivo biodetection, cell labeling and imaging, and nanotherapeutic strategies.
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Sarah J. Hurst, H. Christopher Fry, David J. Gosztola, Daniel Finkelstein-Shapiro, Vladimiro Mujica, Tijana Rajh, "Mechanistic studies into the Raman enhancement of enediol-semiconducting nanoparticle conjugates and their use in biological applications", Proc. SPIE 7758, Physical Chemistry of Interfaces and Nanomaterials IX, 77580E (30 August 2010); doi: 10.1117/12.862931; https://doi.org/10.1117/12.862931
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