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27 August 2010 Nanoscale logic operation in optically manipulated micro-droplets
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Logic gates consisting of DNA molecules are useful for direct processing of information that relates to biomolecules including DNA at nanoscale. This study is aimed at demonstrating operation of the DNA logic gates by optical manipulation of micro-droplets that contain DNA to show potential of photonics techniques in realizing nanoscale computing. Connections of different DNA logic gates are reconfigurable owing to flexibility in manipulating the micro-droplets. The method is effective in, for example, implementing logic operations in limited-volumes at multiple positions in parallel, enhancing an operation rate, and decreasing sample consumption, and it can be a promising technique applicable to photonic DNA computing. We used a two-input and one-output AND or OR gate consisting of DNA in experiments. The individual inputs, A and B, were encoded into different DNA molecules, I1 and I2, and the output was obtained from a fluorescence signal. Input A (B) is 1 when DNA I1 (I2) exists, and 0 when the DNA does not exist. Microdroplets were made by mixing DNA solution, acetophenone as solvent, and sorbitan monooleate as surfactant. For AND/OR operation, two micro-droplets, one of which contained input-DNAs and the other contained AND/OR logic gates, were optically manipulated to be in contact each other; then the micro-droplets coalesced and the operation started. Experimental results show that expected fluorescence intensities are obtained as the output for all possible input values, and logic operation can be implemented successfully in optically manipulated microdroplets.
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Yusuke Ogura, Takahiro Nishimura, and Jun Tanida "Nanoscale logic operation in optically manipulated micro-droplets", Proc. SPIE 7764, Nanoengineering: Fabrication, Properties, Optics, and Devices VII, 77640H (27 August 2010);


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