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17 August 2010 Luminescent conjugated oligothiophenes: optical dyes for revealing pathological hallmarks of protein misfolding diseases
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Abstract
Luminescent conjugated polymers (LCPs) have been frequently utilized for optical biosensors. The detection schemes of these sensors are employing the light harvesting properties or the conformation sensitive optical properties of the conjugated polymers. LCPs have been utilized as colorimetric and fluorescent sensing elements for the recording of biological processes. However, LCPs have several limitations for being used as real time in vivo imaging agents. In this regard, novel thiophene based molecular scaffolds, denoted luminescent conjugated oligothiophenes (LCOs) have been developed. These LCOs are chemically defined molecules having distinct side chain functionalizations and a precise number of thiophene units. Herein the utilization of LCOs as specific ligands for the pathological hallmarks underlying protein misfolding diseases, such as Alzheimer's disease, is described. The use of the conformation sensitive optical properties of the LCOs for spectral separation of these pathological entities in a diversity of in vitro, ex vivo or in vivo systems is demonstrated. The protein aggregates are easily identified due to the conformation-dependent emission profile from the LCOs and spectral assignment of protein aggregates can be obtained. Overall, these probes will offer practical research tools for studying protein misfolding diseases and facilitate the study of the molecular mechanism underlying these disorders.
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Per Hammarström, Mikael Lindgren, and K. Peter R. Nilsson "Luminescent conjugated oligothiophenes: optical dyes for revealing pathological hallmarks of protein misfolding diseases", Proc. SPIE 7779, Organic Semiconductors in Sensors and Bioelectronics III, 77790K (17 August 2010); https://doi.org/10.1117/12.859808
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