Resolution of overlapping skin auto-fluorescence for development of non-invasive applications

Yu-Zheng Su; Li-Wu Lin; Chuen-Yau Chen; Min-Wei Hung; Kuo-Cheng Huang

doi:10.1117/12.859094

7 September 2010 Resolution of overlapping skin auto-fluorescence for development of non-invasive applications

Yu-Zheng Su; Li-Wu Lin; Chuen-Yau Chen; Min-Wei Hung; Kuo-Cheng Huang

Author Affiliations +

Proceedings Volume 7797, Optics and Photonics for Information Processing IV; 77970Y (2010) https://doi.org/10.1117/12.859094
Event: SPIE Optical Engineering + Applications, 2010, San Diego, California, United States

Abstract

Skin auto-fluorescence spectra can provide useful biological information, but the obtained spectrum is overlapped and is difficult to distinguish each contributed component. We applied the genetic algorithm to decompose the overlapping spectrum. First, we simulate the overlapping spectral to confirm our feasible algorithm. The skin auto-fluorescence spectra were obtained from the normal human skin with 337 nm excitation light source. The nicotinamide adenine dinucleotid (NADH) and flavin adenine dinucleotide (FAD) are accurately decomposed and demonstrated. The developed algorithm can be widely applied to achieve qualitative and quantitative analysis for overlapping spectra.

Citation Download Citation

Yu-Zheng Su, Yu-Zheng Su, Li-Wu Lin, Li-Wu Lin, Chuen-Yau Chen, Chuen-Yau Chen, Min-Wei Hung, Min-Wei Hung, Kuo-Cheng Huang, Kuo-Cheng Huang, } "Resolution of overlapping skin auto-fluorescence for development of non-invasive applications", Proc. SPIE 7797, Optics and Photonics for Information Processing IV, 77970Y (7 September 2010); doi: 10.1117/12.859094; https://doi.org/10.1117/12.859094

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