7 September 2010 Resolution of overlapping skin auto-fluorescence for development of non-invasive applications
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Skin auto-fluorescence spectra can provide useful biological information, but the obtained spectrum is overlapped and is difficult to distinguish each contributed component. We applied the genetic algorithm to decompose the overlapping spectrum. First, we simulate the overlapping spectral to confirm our feasible algorithm. The skin auto-fluorescence spectra were obtained from the normal human skin with 337 nm excitation light source. The nicotinamide adenine dinucleotid (NADH) and flavin adenine dinucleotide (FAD) are accurately decomposed and demonstrated. The developed algorithm can be widely applied to achieve qualitative and quantitative analysis for overlapping spectra.
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Yu-Zheng Su, Yu-Zheng Su, Li-Wu Lin, Li-Wu Lin, Chuen-Yau Chen, Chuen-Yau Chen, Min-Wei Hung, Min-Wei Hung, Kuo-Cheng Huang, Kuo-Cheng Huang, } "Resolution of overlapping skin auto-fluorescence for development of non-invasive applications", Proc. SPIE 7797, Optics and Photonics for Information Processing IV, 77970Y (7 September 2010); doi: 10.1117/12.859094; https://doi.org/10.1117/12.859094

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