Evaluation of whole blood coagulation process by optical coherence tomography

Xiangqun Xu; Jia Lin

doi:10.1117/12.869904

8 November 2010 Evaluation of whole blood coagulation process by optical coherence tomography

Xiangqun Xu, Jia Lin

Proceedings Volume 7845, Optics in Health Care and Biomedical Optics IV; 784508 (2010) https://doi.org/10.1117/12.869904
Event: Photonics Asia 2010, 2010, Beijing, China

Abstract

This study was to investigate the feasibility of using optical coherence tomography (OCT) to evaluate whole blood coagulation process. Attenuation coefficients and 1/e light penetration depth (D_1/e) against time of human whole blood during in vitro clot formation under static were measured from the OCT profiles of reflectance vs depth. The results obtained clearly showed that the optical parameters are able to identify three stages during the in vitro blood clotting process. It is concluded that D_1/e measured by OCT is a potential parameter to quantify and follow the liquid-gel transition of blood during clotting.

Citation Download Citation

Xiangqun Xu and Jia Lin "Evaluation of whole blood coagulation process by optical coherence tomography", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 784508 (8 November 2010); https://doi.org/10.1117/12.869904

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