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8 November 2010 Performance of hybrid system for fluorescence and micro-computed tomography in synchronous mode
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Fluorescence diffuse optical tomography (FDOT) plays an important role in studying physiological and pathological processes of small animals in vivo. The low spatial resolution, however, limits the ability of FDOT in resolving the biodistributions of fluorescent markers. The anatomical information provided by X-ray computed tomography (CT) can be used to improve the image quality of FDOT. However, in most hybrid FDOT/CT systems, the projection data sets of optics and X-ray are acquired sequentially, which increases the acquisition time and bring in the unwanted soft tissue displacement. In this paper, we evaluate the performance of a synchronous FDOT/CT system, which allows for faster and concurrent imaging. Compared with previous FDOT/CT systems, the two subsystems (FDOT and CT) acquire projection images in synchronous mode, so the body position can keep consistent in the same projection data acquired by both subsystems. The experimental results of phantom and in vivo experiments suggest that the reconstruction quality of FDOT can be significantly improved when structural a priori information is utilized to constrain the reconstruction process. On the other hand, the synchronous FDOT/CT system decreases the imaging time.
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Xin Liu, Yi Zhang, Fei Liu, Xiaolian Guo, Xin Wang, and Jing Bai "Performance of hybrid system for fluorescence and micro-computed tomography in synchronous mode", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450G (8 November 2010);

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