8 November 2010 Determination of singlet oxygen quantum yield of HiPorfin using Singlet Oxygen Sensor Green
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Abstract
Singlet oxygen (1O2) is widely considered to be the predominant cytotoxic agent for photodynamic therapy (PDT), and the 1O2 quantum yield is a key characteristic for the newly developed photosensitizers. In this study, 1O2 generation from the HiPorfin is monitored indirectly by using the fluorescence probe Singlet Oxygen Sensor Green (SOSG). The good linear relationship between the concentration of HiPorfin and the initial reaction rate of SOSG is observed, and the 1O2 quantum yield of HiPorfin is determined to be 0.124 ± 0.001, as compared to the standard reference of Rose Bengal. The results suggest that SOSG can be useful for 1O2 quantum yield determination for the potential photosensitizers in PDT.
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Huiyun Lin, Yi Shen, Defu Chen, Lisheng Lin, Buhong Li, Shusen Xie, "Determination of singlet oxygen quantum yield of HiPorfin using Singlet Oxygen Sensor Green", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78451J (8 November 2010); doi: 10.1117/12.870108; https://doi.org/10.1117/12.870108
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