8 November 2010 Marginal characteristics of skin scarred dermis quantitatively extracted from multiphoton microscopic imaging
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Abstract
Multiphoton microscopy based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) was applied to examine the marginal regions at dermis of normal, atrophic and keloid scars. High-contrast, high-resolution image showed an obvious boundary at scar margin and different morphological patterns of collagen or elastin on the two sides. Since the degree of the morphological alteration between the two sides of boundary at scar margin was varied among different types of scars, alteration degree of SHG-to-TPEF index was defined as a quantitative indicator for discrimination. It will help to determine the most appropriate clinical treatment strategy for different types of scars and potentially monitor therapy in vivo.
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Xiaoqin Zhu, Shuangmu Zhuo, Liqin Zheng, Xingshan Jiang, Jianxin Chen, Bifang Lin, "Marginal characteristics of skin scarred dermis quantitatively extracted from multiphoton microscopic imaging", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 784528 (8 November 2010); doi: 10.1117/12.869673; https://doi.org/10.1117/12.869673
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