8 November 2010 A novel nasopharyngeal cancer detection based on plasma SERS combined with PCA-LDA statistical analysis
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Abstract
In order to develop a novel and simple blood test for non-invasive nasopharyngeal cancer detection, a surface-enhanced Raman spectroscopy (SERS) method was presented for blood plasma biochemical analysis. High quality SERS spectrum from human plasma-Ag NP mixture can be obtained using a confocal Raman system. SERS measurements were performed on normal and cancer groups of plasma samples. The measured SERS spectra revealed some specific biomolecular differences in nasopharyngeal cancer plasma. Principal component analysis of the measured SERS spectra separated the spectral features of the two groups into two distinct clusters with little overlaps. Linear discriminate analysis based on the PCA generated features differentiated the nasopharyngeal cancer SERS spectra from normal SERS spectra with high sensitivity (97.7%) and specificity (100%). The results from this exploratory study illustrated great promising for developing SERS human plasma analysis into a clinical tool for non-invasive detection of nasopharyngeal cancers.
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Shangyuan Feng, Shangyuan Feng, Juqiang Lin, Juqiang Lin, Jianji Pan, Jianji Pan, Jiesi Chen, Jiesi Chen, Yongzeng Li, Yongzeng Li, Yanan Wu, Yanan Wu, Haishan Zeng, Haishan Zeng, Rong Chen, Rong Chen, } "A novel nasopharyngeal cancer detection based on plasma SERS combined with PCA-LDA statistical analysis", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78452C (8 November 2010); doi: 10.1117/12.870082; https://doi.org/10.1117/12.870082
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