Because of the non-uniformity of sensitive materials, there are serious non-uniformity of the infrared focal plane
arrays (IFFPA). In practical applications, the two-point correction (or multiple-point) is widely used, but the
non-uniformity caused by the time drift results in greatly reduced infrared imaging. Currently, the correction based on the
sense attracts the interests of researchers, which requires the target motion scenes, and narrows the range of applications
and produces the misconvergence phenomenon. The paper proposed a new non-uniformity correction algorithm based on
the two-point correction combined with the information of scene, which can eliminate the non-uniformity of the IFFPA,
time drift, and restrain salt & pepper noise too.