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17 February 2011 Motion correction in spatial frequency domain imaging; optical property determination in pigmented lesions
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Abstract
Background and Objective: Spatial Frequency Domain Imaging (SFDI) is a non-contact wide-field optical imaging technology currently being used to study the optical properties and chromophore concentrations of in-vivo malignant melanomas and benign pigmented lesions. Our objective is to develop a motion correction procedure in order to assess the concerns of subject-motion related variables during clinical measurements. Study Design/Materials and Methods: SFDI motion-correction is a two-part procedure which utilizes a fiduciary marker and canny-edge detection in order to reposition and align the frame-to-frame regions-of-interest (ROI). Motioninduced phase-shifts are subsequently sampled before the entire image-set is processed by a modified demodulation formula. By comparing the results of the adjusted processing method with data gathered from the current non-corrected method, we were able to systematically characterize the impact of motion variables on SFDI measurements. Results: Motion-corrected SFDI data from moving phantom measurements and clinical patient measurements showed up to 84.58% decrease in absorption (μa) variance and up to 92.63% decrease in reduced-scattering (μs') variance. Stationary phantom test-measurements showed almost no difference between motion corrected and standard processing. Conclusion: SFDI motion correction is necessary for obtaining high-fidelity in-vivo optical property measurements of pigmented lesions in a clinical setting.
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John Quan Nguyen, Rolf B. Saager, David J. Cuccia, Kristen M. Kelly, David Hsiang, and Anthony J. Durkin "Motion correction in spatial frequency domain imaging; optical property determination in pigmented lesions", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78830P (17 February 2011); https://doi.org/10.1117/12.876720
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