17 February 2011 Phase contrast imaging of cochlear soft tissue
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A noninvasive technique to image soft tissue could expedite diagnosis and disease management in the auditory system. We propose inline phase contrast imaging with hard X-rays as a novel method that overcomes the limitations of conventional absorption radiography for imaging soft tissue. In this study, phase contrast imaging of mouse cochleae was performed at the Argonne National Laboratory Advanced Photon Source. The phase contrast tomographic reconstructions show soft tissue structures of the cochlea, including the inner pillar cells, the inner spiral sulcus, the tectorial membrane, the basilar membrane, and the Reissner's membrane. The results suggest that phase contrast X-ray imaging and tomographic techniques hold promise to noninvasively image cochlear structures at an unprecedented cellular level.
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Stephanie Shintani Smith, Stephanie Shintani Smith, Margaret Hwang, Margaret Hwang, Christoph Rau, Christoph Rau, Andrew J. Fishman, Andrew J. Fishman, Wah-Keat Lee, Wah-Keat Lee, Claus-Peter Richter, Claus-Peter Richter, } "Phase contrast imaging of cochlear soft tissue", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788323 (17 February 2011); doi: 10.1117/12.882949; https://doi.org/10.1117/12.882949

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