17 February 2011 Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology
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Optical techniques including widefield autofluorescence and reflectance imaging, depth-sensitive optical spectroscopy, and high-resolution imaging can be used to noninvasively detect dysplastic and cancerous alterations in oral tissue. The diagnostic performance of depth-sensitive optical spectroscopy with respect to histopathology is examined. A compact, portable spectroscopy device for clinical use is described. Practical considerations for the comparison of optical measurements to histopathologic diagnoses are outlined. Important considerations for comparison to histopathology include the physical correspondence of the measured region to the biopsy or specimen; data collection and processing procedures; and data analysis procedures. Multimodal combinations of widefield imaging, point spectroscopy, and highresolution imaging may enhance the ability of clinicians to accurately assess the margins of neoplastic oral lesions in vivo.
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Richard A. Schwarz, Richard A. Schwarz, Wen Gao, Wen Gao, Jennifer Nguyen, Jennifer Nguyen, Nadarajah Vigneswaran, Nadarajah Vigneswaran, Karen Adler-Storthz, Karen Adler-Storthz, Vijayashree S. Bhattar, Vijayashree S. Bhattar, Michelle D. Williams, Michelle D. Williams, Ann M. Gillenwater, Ann M. Gillenwater, Rebecca Richards-Kortum, Rebecca Richards-Kortum, } "Real-time spectroscopic evaluation of oral lesions and comparisons with histopathology", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832K (17 February 2011); doi: 10.1117/12.887758; https://doi.org/10.1117/12.887758

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